Interestingly, NLRP3 inflammasome activation modulates dopaminergic neuronal cell death via pyroptotic mechanisms [44], and NLRP3 inflammasome inhibition can rescue dopaminergic neuronal loss, improve motor dysfunction, and alleviate neuroinflammation in rodent models of PD [16,18,45,46,47]. Here, NLRP3 is linked to Parkinson disease.