Importantly, for POAG, for instance, researchers were able to link POAG to defects in myocilin [26,27,37], to retinal nerve fiber disease [50], Cacna2d1 regulation in elevated IOP [20,30,31,35,51,52], defects in the proteome of human scleral tissue [53], and that of the central cornea [31,34,40,54]. Here, CACNA2D1 is linked to open-angle glaucoma.