Both Abelacimab and antisense oligonucleotides were superior to Enoxaparin in preventing a postoperative venous thromboembolism; however, antisense oligonucleotides must be used for one month prior to surgery to decrease FXI to therapeutic concentrations, whereas the functional factor XI level decreased within minutes following intravenous administration of Abelacimab, which permitted its postoperative administration. The gene discussed is F11; the disease is venous thromboembolism.