ABCA1 and Tangier disease: In previous studies, structural analyses and post-heparin-lipolytic activities of VLDL isolated from Tangier’s disease patients showed that a lack of functional ABCA1 results in the abnormal apolipoprotein composition of VLDL, reduced reactivity of VLDL-triglycerides with plasma lipoprotein lipase (LPL), and hypertriglyceridemia [31,33].