The systemic effects of GLP-1 and its analogs on various vital tissues and organs include reduction of insulin resistance, decrease in hyperglycemia, loss of body weight, reduction of blood pressure, decrease in reactive oxygen species (ROS) production, modulation of the inflammatory response, and improvement of reproductive function (Table 2, Figure 3) [38,44,45]. The gene discussed is GLP1R; the disease is Hyperglycemia.