IDH2 and Duchenne muscular dystrophy: They described several nuances of DMD muscles indicating metabolic disease, including the empirical observations that: (1) DMD myofibers were tacky due to surface lipid accumulation, which was traced back to the focal dysfunction of the tricarboxylic acid (TCA) cycle enzyme, isocitrate dehydrogenase (IDH), a significant control point of mitochondrial adenosine triphosphate (ATP) synthesis [2,3]; and that this liposis was associated with (2) the loss of muscle elastic elements [4] and (3) fibrosis of the extracellular matrix (ECM) [4].