In line with these findings neither T levels nor AR gene polymorphisms are associated with osteoporosis in patients with KS [34], and testosterone replacement therapy (TRT) in hypogonadal KS men has been shown to solely increase lumbar spine BMD, with no effects on the hip or on bone quality measures, [35] crediting the hypothesis that FSH might play a role in bone health. The gene discussed is BRD2; the disease is osteoporosis.