TNFSF10 and neoplasm: In another study, Kauer et al., engineered a simulated extracellular matrix (sECM) composed of hyaluronic acid and PEG diacrylate-based hydrogel to encapsulate stem cells that released a tumor-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in the tumor resection cavity over a period of 12 days, which eradicated residual tumor cells and significantly increased survival in a patient-derived xenograft GBM model [58].