Furthermore, 100 kg/mL of aqueous roselle extract exhibited in vitro and in vivo the attenuation of cardiac oxidative stress by decreasing the gene expression of oxidative stress (NOX2 and 8-isoprostane level) and increasing the level of antioxidants (SOD and GSH level) in post-myocardial infarction rats [67]. The gene discussed is SOD1; the disease is myocardial infarction.