However, in early-stage cervical squamous cell carcinoma tissues and CCa cell lines, its RNA and protein expression are downregulated; this reduction has been correlated with clinicopathologic tumor features, such as tumor growth, tumor type, tumor size, and differentiation grade, as well as shorter overall survival, identifying TRPV6 as a prognostic factor for early CCa patients [74]. This evidence concerns the gene TRPV6 and neoplasm.