TRPV1 and cervical intraepithelial neoplasia: One of the most studied channels in CCa is TRPV1, which is overexpressed in CCa tissues, compared with cervical intraepithelial neoplasia and normal epithelial tissue; in contrast, the tumor suppressor phosphatase and tension homolog (PTEN) expression is reduced in CCa, and the determination of both molecules (high TRPV1/low PTEN) has been proposed as a prognosis biomarker [67].