Potassium channels are aberrantly expressed in different cancer cell lines and cancer tissues [6], and there is mounting evidence that supports the association of potassium channels with the hallmarks of cancer, including cell proliferation, invasion, and migration; in accordance, blocking or suppressing their expression or activity has antineoplastic features in different types of tumors in both, in vitro and in vivo studies, strongly suggesting them as candidates for targeted therapy [7]. This evidence concerns the gene KCNA3 and cancer.