SCN8A and cervical carcinoma: In HPV16- positive cervical cancer (CCa) biopsies and in cervical cancer primary cell cultures, NaV1.6 and Nav1.7b mRNA overexpression was found when compared to non-cancerous biopsies; although protein expression was found in CCa and non-cancerous samples by immunohistochemistry, the pattern of positive cells was more widely distributed in all the sections of squamous epithelial tissue in CCa biopsies [49].