Moreover, under eye disease conditions as in OAG, the ECM elements are abnormally overproduced due to the release of transforming growth factor-β1/2 (TGF-β1/2) which up-regulates connective tissue growth factor (CTGF) [43,44,46,48], with resultant excess deposition of ECM components and mutant myocilin [42]. Here, CCN2 is linked to eye disorder.