In addition, the HA-modified poly lactic-co-glycolic acid (PLGA)-PEG nanoparticles (PLGA-PEG-HA NPs) could target and deliver thiotetrazole, a suppressor of PI3K, to CD44 overexpressing pancreatic cancer cells, thereby improving the efficacy of anti-cancer drugs and inducing tumor cell premature senescence through the inhibition of the PI3K/AKT/NF-κB signaling pathway in pancreatic cancer [156]. The gene discussed is AKT1; the disease is pancreatic neoplasm.