The HA-GC-DOX/CXB system obviously downregulates cyclooxygenase (COX), MMPs, and NF-κB, as well as increases the expression of caspase 3, thereby significantly suppressing NSCLC tumor inflammation, proliferation, invasiveness, and enhancing apoptosis [155]. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.