Furthermore, NF-κB could induce the transition of macrophage in the tumor microenvironment from M2 to M1 phenotype and decrease the level of inflammatory factors (IL-10, TGF-β and PGE2) which could prevent cytotoxic T-cells, thereby upregulating the expression of PD-1 in T-cells and potentiating the sensitivity to anti-PD-1 therapy of HCC [151]. The gene discussed is NFKB1; the disease is neoplasm.