Moreover, NF-κB facilitates Bax activation and cytC release and further induces the activity of caspase 3 and degradation of GSDME to promote cell pyroptosis and exert anti-cancer effects in HCC, breast cancer, and CRC under the stimulation of the metformin-enhanced AMPK/SIRT1 pathway [69]. This evidence concerns the gene NFKB1 and colorectal carcinoma.