Insulin resistance and hyperglycemia can activate the NLRP3 (NOD (nucleotide oligomerization domain)-, LRR (leucine-rich repeat)-, and PYD (pyrin domain)-containing protein 3) inflammasome, leading to the release of cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-α. The gene discussed is NLRP3; the disease is Hyperglycemia.