However, whether TYCA06, BLI-02, and VDD088 ameliorate hyperglycemia through modulating insulin levels and protecting islet cells in db/db mice should be investigated [30]; similarly, whether TYCA06, BLI-02, and VDD088 reduce blood pressure by regulating plasma vasopressin (also known as the antidiuretic hormones) or the renin–angiotensin system should be verified in future research (Figure 4a,b) [31]. This evidence concerns the gene REN and Hyperglycemia.