The linking mechanism and the complications between obesity and inflammation are well-documented in the literature, which indicates that the excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as TNF-α and IL-6 and reduces the production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.