TNF and colorectal carcinoma: The main findings of the NMA are shown in Figure 2B. Compared with placebo, glutamine (MD −25.2; 95% CrI [−32.62, −17.95]) and probiotics (MD −12.55; 95% CrI [−15.19, −9.92]) significantly reduced TNF-α levels in CRC patients (Figure 2B).