MAPT and Alzheimer disease: In vitro test:Cell viability, Mitochondrial membrane potential (MMP) depolarization ↑Nuclear apoptosis, ROS, Caspase-3 activity ↓In vivo test:AD-like behavior, TUNEL-positive apoptotic neurons, AchE level, ROS, the expression of Aβ in the hippocampus, 4-NHE levels, and p-Tau aggregation ↓Ach level, ChAT level, SOD and GSH-Px level, serum Aβ1-42 concentrations ↑