NFKB1 and neoplasm: In tumor angiogenesis, SFN inhibits NF-κB-regulated VEGF expression in human prostate cancer cells [136]; Peng liu et al. showed that SFN interferes with the proliferation, migration, and tube formation of endothelial cells, but it is also capable of inhibiting the pro-angiogenic effect of HepG2 cells both in vitro, ex vivo, and in vivo.