Vitamin D levels, as well as VDR expression, decrease with age, which is of particular importance for postmenopausal women, who, due to the cessation of estrogen synthesis and the consequent lack of its protective effect, are at greater risk of reduced bone mass, cardiovascular disease, metabolic disorders, unfavorable lipid profiles, diabetes, and atherosclerosis with all of its long-term consequences [22,23,24]. This evidence concerns the gene VDR and Other metabolic disease.