A comparison of metabolic genes between the KD- and HF/LC-treated mice showed significant upregulation of glucose 6 phosphatase catalytic subunit 2 (G6pc2), HNF1a, glutaminase 2 (Gls2), and insulin 1 (Ins1) in the HF/LC-treated group compared to the KD-treated group, while the remainder of genes were not significantly upregulated in either group (Figure 4B). This evidence concerns the gene G6PC2 and hydrops fetalis.