In two large cohorts of CRC patients from the UK, a strong inverse association between 25-hydroxyvitamin D (25(OH)D), the best-established biomarker of VitD status, and CRC-specific survival was observed among patients with the GG genotype of rs11568820 (also known as Cdx2), a functional polymorphism located in the promotor region of the VDR gene, whereas this association was not seen among other patients [7]. This evidence concerns the gene VDR and colorectal carcinoma.