Sarcopenic obesity has been associated with varying increases of inflammatory factors—specifically IL-6, C-reactive protein, IL-1 receptor antagonist, and soluble IL-6 receptor [42]—and while vitamin D has been shown to reduce pathological levels of inflammation (particularly interleukin 6 [43]), it could arise that resulting shifts in metabolic demand (resulting from obesity-related inflammation [44]) might overwhelm the influence vitamin D has on maintaining musculoskeletal homeostatic processes. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.