For instance, hyperglycemia and dyslipidemia can trigger the overexpression of vascular NADPH oxidase for superoxide (O2−) radical generation, leading to the repression of endothelial nitric oxide synthase (eNOS) expression, increased production of a potent vasoconstrictor called endothelin-1 (ET-1), and activation of inflammatory pathways [7,8,9]. The gene discussed is EDN1; the disease is Hyperglycemia.