LYZ and pachyonychia congenita: Markers used for validation and projection of each cluster are shown (Figure S1B), including Epithelial Cell Adhesion Molecule (EPCAM) to identify all the epithelial cells, lysozyme (LYZ) to identify PC, mucin 2 (MUC2) to identify GC, and chromogranin B (CHGB) to identify EEC.