Fourteen genes corresponding to two gene sets were identified, and the functional dyspepsia-related genes targeted by the activated F. fructus compound were ADRA2A, BDNF, CCK, CRP, GCG, JUN, Kcnh2, PTGS1, PTGS2, Pyy, SLC6A4, and TRPV. This evidence concerns the gene KCNH2 and dyspepsia.