Overexpression of FTO induced obesity in mice, associated with increased triglyceride deposition, whilst knockdown of FTO caused adipose tissue atrophy [21,22,23]; furthermore, FTO overexpression promoted adipogenesis in preadipocytes, murine embryonic fibroblasts, and porcine intramuscular preadipocytes [23,24,25,26]. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.