Considering that IL-4 is a crucial cytokine to induce the immunoglobulin class-switching [48], our results open a new question regarding the relevance of the CD5+ B cells to favor the pro- and anti-inflammatory profile and evaluate if the IL-4 induced by proteins (like in UC) or by lipid (like in LTB and DS-TB) use the same mechanisms of regulation. Here, CD5 is linked to tuberculosis.