TLR2 and leptospirosis: Although beneficial effects of trained immunity on leptospirosis have been reported through host-directed treatment using a TLR2/NOD2 agonist (CL429) [132] and proposed as an adjuvant to increase the efficiency of leptospiral vaccines, deeper studies are needed to characterize the type of immune modulation induced by rBCG expressing leptospiral antigens.