IGHE and allergic disease: The comparison of the in vitro tests results documented a significant statistical difference (p-value: 0.046) in the median values for Anisakis (p4)-specific IgE levels between the Anisakis allergy group (mean ± SD = 13.2 ± 26.1) and the chronic urticaria group (mean ± SD = 13.2 ± 26.1).