KEGG pathway analysis showed that the main pathways enriched in differentially expressed proteins were drug metabolism-cytochrome P450, glyoxylate, dicarboxylate metabolism, retinol metabolism, PPAR carbon signaling pathway, peroxisome, butanoate metabolism, ascruvate metabolism, ascorbate, alternate metabolism enzymes, and drug metabolism, the other top 10 most significant enrichment pathways (Figure 8b), indicating that MG may be involved in the treatment of α-naphthyl isothiocyanate-induced cholestasis mice through the above signaling pathways. The gene discussed is PPARA; the disease is cholestasis.