Several mitophagy adaptors, such as a parkin, PINK1, bifunctional mitochondrial protein (BNIP3), autophagic indicator (P62/SQSTM1) and signaling pathways (nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/PINK1/Parkin pathway), are impaired in cancer [75]. The gene discussed is SQSTM1; the disease is cancer.