For the same indicators in the same group, the decrease percentage in serum was smaller than that in joint fluid, which may be due to the higher expression of these indicators in RA joints than in serum, while TPL exerts its anti-RA effect mainly by reducing the levels of inflammatory factors such as hs-CRP, IL-1, IL-6, and TNF-α. This evidence concerns the gene IL1A and rheumatoid arthritis.