Group 1 ILCs (ILC1s), which includes NK cells, primarily produce IFN-γ and TNF-α and are involved in immunity to bacteria, viruses, and cancer, while Group 3 ILCs (ILC3s) produce IL-22, IL-17A, and IFN-γ and are involved in immunity to bacteria, chronic inflammation, and lymphoid development. The gene discussed is IFNG; the disease is cancer.