There are several signaling pathways associated with the inflammatory response; they have been implicated within atherosclerosis such as the NLRP3 inflammasome, Toll-like receptors, proprotein convertase subtilisin/kexin type 9, and the Notch and Wnt signaling pathways: all of these are important for atherosclerosis development and progression. This evidence concerns the gene PCSK9 and atherosclerosis.