In our study [110], we studied oral dysbiosis, i.e., the altered abundance of Pg and Fn, and its relationship to previous ASCVD in patients at high/very high risk for CVD, with or without HeFH, compared to matched healthy controls, finding that greater oral Pg abundance is present in very high-risk patients with previously diagnosed ASCVD and suggesting a potential relationship with CV events. The gene discussed is JUP; the disease is atherosclerosis.