A large Mexican study also observed an increased prevalence of DM in women, but with a mean GH value higher in men [30], an aspect not present in our population of acromegalic patients (. The general prevalence of DM is higher in men, but this aspect changes after the age of menopause when metabolic alterations lead to the impairment of insulin secretion and insulin sensitivity [31]. Here, GH1 is linked to diabetes mellitus.