IGF1 and cancer: Growth hormone/insulin growth factor-1 (GH/IGF-1) axis has been associated with cancer risk due to its involvement in cell multiplication through mitogen-activated protein kinase (MAPK) signaling [10], and it also enables the mammalian target of rapamycin pathway (mTOR), which is involved in the genesis of tumors in tissues from obese and/or diabetic mice [8].