ALDH2 and major depressive disorder: The co-occurrence of ALDH2 rs671(GG) and ADH1B rs1229984(GG) alleles has been recently related to anxiety, depression, and alcohol-related disorders [89], and the ALDH2 rs671(A), in combination with the MAOA-uVNTR (variable number of tandem repeat located upstream) 4-repeat variants, could reduce the risk of anxiety, depression, and alcohol dependence [90].