Subsequently, all important variables such as Wnt2, T stage, M stage, N stage, TNM stage, and BRAF mutation status were entered into the multivariate Cox proportional hazards model, and the results showed that Wnt2 expression (p = 0.035) and BRAF mutations (p < 0.0001) were prognostic factors for poor OS in CRC (Table 3). Here, BRAF is linked to colorectal carcinoma.