BRAF and colorectal carcinoma: Univariate analysis showed that Wnt2 (p < 0.0001), T stage (p = 0.008), M stage (p < 0.0001), N stage (p < 0.0001), TNM stage (p < 0.0001), and BRAF mutation status (p < 0.0001) were significantly associated with poor prognosis in CRC (Table 3).