In the Dialysis Patients Response on IV Iron with Elevated Ferritin (DRIVE) study, an intensive iv iron administration protocol (125 mg ferric gluconate for eight HD sessions) can significantly reduce ESA dosing requirements in patients who have a ferritin level > 500 ng/mL and a TSAT < 25% when also receiving adequate epoetin [28]. The gene discussed is EPO; the disease is renal dialysis.