In SLE, autoreactive T cells can increase the expression of apoptotic ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and Fas ligand (FasL) which will directly facilitate monocyte apoptosis [20,23]. The gene discussed is FASLG; the disease is systemic lupus erythematosus.