They interact with leukocytes and endothelial cells of blood vessels; activate and induce adhesion and transport of monocytes; participate in the release of interleukin 1 (IL-1), tumor necrosis factor, and other factors of inflammation; and are involved in the processes of local myocarditis and myocardial fibrosis in patients with valve pathology [40]. The gene discussed is TNF; the disease is Myocardial fibrosis.