Although double thrombophilia carries a greater risk of arterial thrombosis than either thrombophilia taken separately (Table 1), the risk of arterial thrombotic events—including MI, ischemic stroke, transient ischemic attack, and peripheral arterial thrombotic event—of those with FV Leiden and prothrombin G20210A is still ten times lower than their risk of VTE [62]. This evidence concerns the gene F2 and Rare hereditary thrombophilia.