However, there are some exceptions that justify screening for these two thrombophilic mutations in survivors of an acute MI: (a) the event occurred in individuals under the age of 45; (b) the absence of traditional cardiovascular risk factors such as hypertension, dyslipidemia, obesity, diabetes, and smoking; (c) MI in the absence of a flow-limiting artery lesion at coronary angiography (MINOCA); (d) family history of VTE at a young age; (e) family history of FV Leiden or prothrombin G20210A mutation; and (f) women smokers younger than 50 years [108,109,110]. The gene discussed is F2; the disease is obesity due to melanocortin 4 receptor deficiency.