They demonstrated that both the compound mutant (TET2 −/−; Ob/Ob, DNMT3A +/−; Ob/Ob, ASXL1 +/−;Ob/Ob and JAK2 +/−; Ob/Ob) and CHIP mutant bone marrow (BM; TET2 −/−, DNMT3A +/−, ASXL1 +/− and JAK2 +/−) transplanted into Ob/Ob mice resulted in the rapid growth of mature myeloid cells and hematopoietic stem/progenitor cells, leading to a severe form of MPN/AML and CVD. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.