STUB1 and obesity due to melanocortin 4 receptor deficiency: -An increase in WHR was linked to the existence of the CHIP mutation. Additionally, CHIP prevalence rose in correlation with greater WHR-Obesity-driven CH was confirmed on mice models-A combination of metformin/nifedipine/MCC950/anakinra was demonstrated to be both secure and efficacious in averting CH and its associated risks