The researchers identified two novel lncRNAs (MIR100HG and LINC01105) associated with AF that may function by co-expressing with (MIR100HG-ROCK1/FBXW7/UBE2D1, LINC01105-EGFR) mRNAs or sponging miRNAs for mRNAs (LINC01105-miR-125a-3p-EGFR, MIR100HG-miR-200b-3p-FBXW7, MIR100HG-miR-561-3p-CXCR2) to regulate cardiomyocyte apoptosis and atrial fibroblast proliferation, ultimately leading to the development of the disease [45]. This evidence concerns the gene CXCR2 and atrial fibrillation.