When the last analysis for model 3 was performed for women with MAPs before 20 weeks of gestation and PAPP-A values, the MAPs and MoM values of PAPP-A were significantly associated with PAH (OR: 1.055, 95% CI: 1.036–1.075 and OR: 0.473, 95% CI: 0.265–0.844, respectively) (Table A2). Here, PAPPA is linked to pulmonary arterial hypertension.