PAPPA and pulmonary arterial hypertension: When the last analysis for model 3 was performed for women with MAPs before 20 weeks of gestation and PAPP-A values, MAPs and MoM values of PAPP-A were significantly associated with PAH (OR: 1.081, 95% CI: 1.056–1.10 and OR: 0.417, 95% CI: 0.181–0.959, respectively) (Table A3).