NPPB and hydrops fetalis: In an early and reversible stage of the disease, sacubitril/valsartan can prevent global cardiac remodeling, and this was sustained by the results of the PIONEER-HF trial (Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode) [105].