However, the sex-stratified analysis detected that SNPs rs648595 (OR = 0.56, 95% CI 0.35–0.90; Pperm = 0.017, recessive model) and rs2397147 (OR = 0.54, 95% CI 0.30–0.98; Pperm = 0.05, recessive model) of the GCLC gene were associated with susceptibility to psoriasis in males. The gene discussed is GCLC; the disease is psoriasis.