Polymorphisms of the GCLC gene have been found to be associated with the risk of cardiometabolic diseases such as coronary artery disease [52,53], ischemic stroke [54], type 1 [55,56] and type 2 [51] diabetes mellitus, polycystic ovary syndrome [57], and nonalcoholic fatty liver disease [58], as well as other multifactorial disorders such as bronchial asthma [59], pulmonary tuberculosis [60], and colorectal cancer [61]. Here, GCLC is linked to metabolic dysfunction-associated steatotic liver disease.