In the Ferric Iron in Heart Failure (FERRIC-HF) trial, intravenous iron sucrose was associated with increased transferrin saturation (p < 0.05), serum ferritin (p < 0.01), NYHA functional class (p < 0.01) compared with no treatment but without changes in hemoglobin (Hb ≤ 12.5 g/dL) [38]. Here, TF is linked to heart failure.