ACHE and Alzheimer disease: On the contrary, drug targets for symptomatic treatments for AD include (A) acetylcholinesterase (AChE) inhibition, (B) N-methyl-D-aspartate (NMDA) receptor modulation, (C) nicotinic acetylcholine receptor activation, (D) gamma-aminobutyric acid receptor blockade, (E) serotonin receptor activation and blockade, (F) histamine H3 receptor blockade, and (G) phosphodiesterase inhibition [4].