APC and colorectal carcinoma: Zhang et al. revealed that PEAC molecular profiles resemble lung cancer, including ERBB2, EGFR and ALK mutations accounting for 75% of cases; on the other hand, MRC and CRC involve alterations of adenomatous polyposis coli (APC) genes, the KRAS pathway and mutation of mismatch repair genes (MSH6, PMS, MLH1).