Zhang et al. revealed that PEAC molecular profiles resemble lung cancer, including ERBB2, EGFR and ALK mutations accounting for 75% of cases; on the other hand, MRC and CRC involve alterations of adenomatous polyposis coli (APC) genes, the KRAS pathway and mutation of mismatch repair genes (MSH6, PMS, MLH1). The gene discussed is APC; the disease is lung cancer.