The major signaling mechanisms involved in the process of CKD include NLRP3 inflammasome, MAPK, PI3K/Akt, and RAAS signaling in lipotoxicity; mTORC, MAPK, PKB, and NF-κB signaling in oxidative stress; NF-κB, NLRP3 inflammasome, JAK-STAT, Toll-like receptor, and cGAS-STING in inflammation; and TGF-β, Wnt, RAAS, and Notch signaling in myofibroblast activation and ECM accumulation [73]. This evidence concerns the gene AKT1 and chronic kidney disease.